A Live Zebrafish-Based Screening System for Human Nuclear Receptor ...Nuclear receptors (NRs) belong to a superfamily of transcription factors that regulate numerous homeostatic, metabolic and reproductive processes. Taken together with their modulation by small lipophilic molecules, they also represent ... Continue reading
Levels of 17β-Estradiol Receptors Expressed in Embryonic and Adult ...The nuclear receptors encompass a group of regulatory proteins involved in a number of physiological processes. The estrogen receptors (ERs), of which one alpha and one beta form exist in mammals function as transcription factors in ... Continue reading
Stem Cell Networks in ZebrafishUsing the zebrafish as an experimental model, a team of systems biologists from the University of Freiburg led by Prof. Dr. Wolfgang Driever and Dr. Daria Onichtchouk from the Faculty of Biology and Prof. ... Continue reading
PLoS ONE: Structural Requirements for PACSIN/Syndapin Operation ...Combined structural, biochemical and reverse genetic approaches in zebrafish define an important role for Syndapin orthologue, Pacsin3, in the early formation of the notochord during embryonic development. In pacsin3-morphant embryos, ... Continue reading
Stem Cell Networks in ZebrafishEmbryonic stem cells (ES cells) have invaluable potential for regenerative medicine. Scientists are only just beginning to understand the diverse developmental possibilities (“pluripotency”) of ES cells. The Pou5f1/Oct4 protein is one ... Continue reading
Novel intronic microRNA represses zebrafish myf5 promoter activity ...A strong, negative cis-element located at the first intron +502/+835 (I300) of zebrafish myf5 has been reported. To elucidate the molecular mechanism underlying this repression network, we microinjected zebrafish single-cell embryos ... Continue reading
Pocket Science - chameleons hunt with cold-proof tongues and ...At five days of age, baby zebrafish have just used up all the yolk from their eggs and are starting to find their own food. For them, energy is a precious commodity and eyes are energy-guzzling appliances, even when they're set to ... Continue reading
Zebrafish used to visualize blood stem cell generationTwo new studies in the journal Nature have leveraged the unique powers of the zebrafish as a model vertebrate to provide answers to this question. George Streisinger of the University of Oregon first developed this cute little pet store ... Continue reading
Gene Expression Differences Between the Zebrafish and Sea SquirtThe zebrafish and the sea squirt, for all of their differences, share a common development stage. At an analogous development stage the two species share a tadpole larval body plan. But new research shows some surprising differences in ... Continue reading
JoVE: Dissection of Organs from the Adult Zebrafish (Video Protocol)Over the last 20 years, the zebrafish has become a powerful model organism for understanding vertebrate development and disease. Although experimental analysis of the embryo and larva is extensive and the morphology has been well ... Continue reading
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